Most clients do not find the procedure to be painful, and it requires no anesthetic. The esthetician will instruct you to relax as she applies the wand to your face in a slow, methodical way. One microdermabrasion treatment should take 30 minutes to an hour. There are no side effects, and your skin will look glowing and fresh almost immediately after the treatment. Some more aggressive treatments may cause the skin to look slightly pink and tender for a few hours afterward. You can resume normal activities and apply makeup and moisturizer directly after your microdermabrasion session.